Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors

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Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.

Angiogenesis is the process of neovascularization from parent blood vessels, which is a prerequisite for many physiological and pathological conditions and is regulated by a balance between endogenous angioinhibitors and angioactivators or angiogenic factors. Imbalance between angioinhibitors and angioactivators is associated with neovascularization capacity during progression of tumor developm...

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Regulation of Angiogenesis in Choroidal Neovascularization of Age Related Macular Degeneration by Endogenous Angioinhibitors

The sense of vision has utmost significance and the loss of vision leads to the impairment of active human behavior as evident in pathological disorders that affect vision. Among different pathological visual disorders, Age Related Macular Degeneration (AMD/ARMD) is of serious concern as a leading cause of blindness, observed with aging globally. The clinical manifestation of AMD includes retin...

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Endogenous endostatin inhibits choroidal neovascularization.

Endostatin, a fragment of the basement membrane component collagen XVIII, exhibits antiangiogenic properties in vitro and in vivo when high doses are administered. It is not known whether endogenous endostatin at physiological levels has a protective role as an inhibitor of pathological angiogenesis, such as choroidal neovascularization (CNV) in age-related macular degeneration. Using a laser i...

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Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters.

MicroRNAs (miRNAs) modulate complex physiological and pathological processes by repressing expression of multiple components of cellular regulatory networks. Here we demonstrate that miRNAs encoded by the miR-23∼27∼24 gene clusters are enriched in endothelial cells and highly vascularized tissues. Inhibition of miR-23 and miR-27 function by locked nucleic acid-modified anti-miRNAs represses ang...

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Inhibition of choroidal neovascularization by homoisoflavanone, a new angiogenesis inhibitor

PURPOSE Age-related macular degeneration (AMD) is the leading cause of blindness in elderly. The detailed mechanism of choroidal neovascularization (CNV) leads to severe vision loss in patients with AMD. This study was undertaken to evaluate the inhibitory effect of homoisoflavanone on CNV. METHODS Antiangiogenic activity of homoisoflavanone was evaluated by in vitro tube formation assay of h...

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ژورنال

عنوان ژورنال: Journal of Cancer Science & Therapy

سال: 2013

ISSN: 1948-5956

DOI: 10.4172/1948-5956.1000235